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Mouse Anti-FBXO4 Recombinant Antibody (2F2) (CBMAB-F1955-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F2
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
FBXO4 (AAH48098, 1 a.a.-387 a.a) full-length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-box protein 4
Introduction
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
26272
UniProt ID
Q9UKT5
Alternative Names
F-Box Protein 4; F-Box Only Protein 4; FBX4; F-Box Protein Fbx4;
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.
Biological Process
Aging Source: Ensembl
Cellular homeostasis Source: Ensembl
Cellular response to ionizing radiation Source: Ensembl
Common myeloid progenitor cell proliferation Source: Ensembl
Negative regulation of fibroblast proliferation Source: Ensembl
Negative regulation of protein localization to nucleus Source: Ensembl
Positive regulation of protein polyubiquitination Source: Ensembl
Positive regulation of protein ubiquitination Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Posttranscriptional regulation of gene expression Source: Ensembl
Protein destabilization Source: Ensembl
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of DNA damage checkpoint Source: Ensembl
Regulation of protein stability Source: BHF-UCL
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Telomere maintenance Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Cytoplasm
PTM
Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1.
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For research use only. Not intended for any clinical use.

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