FCGR2C

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

Full Name

Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene)

Research Area

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: UniProtKB
Regulation of immune response Source: GO_Central

Cellular Location

Isoform IIC4: Cytoplasm
Isoform IIC1&2&3: Cell membrane

Topology

Extracellular: 43-223
Helical: 224-246
Cytoplasmic: 247-323

PTM

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.

Anti-FCGR2C antibodies

Rabbit Anti-FCGR2C Recombinant Antibody (EG1185) (CBMAB-EN1428-LY)

Datasheet

SDS

Target: FCGR2C

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1185

Application*: WB: 1:500~1:1000 ELISA: 1:40000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)