Rabbit Anti-FCGR2C Recombinant Antibody (EG1185) (CBMAB-EN1428-LY)

The product is antibody recognizes FCGR2C. The antibody EG1185 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all FCGR2C antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG1185

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human FCGR2C.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene)

Introduction

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]

Entrez Gene ID

9103

UniProt ID

P31995

Alternative Names

Fc Fragment Of IgG Receptor IIc (Gene/Pseudogene); Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32); IgG Fc Receptor II-C; Fc-Gamma-RIIc; CDw32; IGFR2; FCG2; CD32; Fc Fragment Of IgG, Low Affinity IIc, Receptor For (CD32) (Gene/Pseudogene); Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C;

Research Area

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: UniProtKB
Regulation of immune response Source: GO_Central

Cellular Location

Isoform IIC4: Cytoplasm
Isoform IIC1&2&3: Cell membrane

Topology

Extracellular: 43-223
Helical: 224-246
Cytoplasmic: 247-323

PTM

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.

References

Ebonwu, J., Lassaunière, R., Paximadis, M., Goosen, M., Strehlau, R., Gray, G. E., ... & Tiemessen, C. T. (2021). An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition. Frontiers in immunology, 12, 760571.

Lehmann, D., Unterthurner, S., Berg, V., Hock, K., Ponnuswamy, P., Malisauskas, M., ... & Bilic, I. (2021). Comprehensive approach for identification of functional FCGR2C alleles resulting in protein expression as a determinant for predicting predisposition to autoimmunity. ImmunoMedicine, 1(2), e1027.

Lassaunière, R., Paximadis, M., Ebrahim, O., Chaisson, R. E., Martinson, N. A., & Tiemessen, C. T. (2019). The FCGR2C allele that modulated the risk of HIV-1 infection in the Thai RV144 vaccine trial is implicated in HIV-1 disease progression. Genes & Immunity, 20(8), 651-659.

Bonatti, F., Adorni, A., Percesepe, A., & Martorana, D. (2018). Discrimination of FCGR2B polymorphism without coamplification of FCGR2A and FCGR2C genes. International Journal of Immunogenetics, 45(1), 22-25.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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