FEZ1

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Full Name

Fasciculation And Elongation Protein Zeta 1

Research Area

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Biological Process

Axon guidance Source: ProtInc
Cell adhesion Source: ProtInc
Cellular response to growth factor stimulus Source: Ensembl
Establishment of cell polarity Source: Ensembl
Establishment of mitochondrion localization Source: Ensembl
Hippocampus development Source: Ensembl
Mitochondrion morphogenesis Source: Ensembl
Negative regulation of autophagosome assembly Source: GO_Central
Nervous system development Source: ProtInc
Positive regulation of anterograde axonal transport of mitochondrion Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl

Cellular Location

Centrosome; Cell membrane. Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity).

PTM

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26.