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Rabbit Anti-FEZ1 Recombinant Antibody (D9R8Q) (CBMAB-CP0695-LY)

The product is antibody recognizes FEZ1. The antibody D9R8Q immunoassay techniques such as: WB,IP.
See all FEZ1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D9R8Q
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human FEZ1 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fasciculation And Elongation Protein Zeta 1
Introduction
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9638
Mouse235180
Rat81730
UniProt ID
HumanQ99689
MouseQ8K0X8
RatP97577
Alternative Names
Fasciculation And Elongation Protein Zeta 1; Zygin I; Zygin-1; Fasciculation And Elongation Protein Zeta-1; UNC-76;
Research Area
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.
Biological Process
Axon guidance Source: ProtInc
Cell adhesion Source: ProtInc
Cellular response to growth factor stimulus Source: Ensembl
Establishment of cell polarity Source: Ensembl
Establishment of mitochondrion localization Source: Ensembl
Hippocampus development Source: Ensembl
Mitochondrion morphogenesis Source: Ensembl
Negative regulation of autophagosome assembly Source: GO_Central
Nervous system development Source: ProtInc
Positive regulation of anterograde axonal transport of mitochondrion Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Cellular Location
Centrosome; Cell membrane. Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity).
PTM
Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26.

Razar, R. B. B. A., Qu, Y., Gunaseelan, S., & Chua, J. J. E. (2022). The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders. Neural Regeneration Research, 17(6), 1165.

Malikov, V., Meade, N., Simons, L. M., Hultquist, J. F., & Naghavi, M. H. (2022). FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression. Cell reports, 38(7), 110396.

Chua, J. Y., Ng, S. J., Yagensky, O., Wanker, E. E., & Chua, J. J. E. (2021). FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development. Eneuro, 8(2).

Zhang, Y., Shi, Q., Li, X., & Xia, C. (2020). Fasciculation and Elongation Protein Zeta-1 Expression in Reactive Astrocytes in a Rat Model of Frontal Lobe Injury. Journal of Neuropathology & Experimental Neurology, 79(2), 194-208.

Demir, M., Yilmaz, U., Colak, C., Cigremis, Y. I. L. M. A. Z., Ozyalin, F., Tekedereli, I., & Sandal, S. (2019). Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?. Bratislavske Lekarske Listy, 120(1), 70-77.

Teixeira, M. B., Alborghetti, M. R., & Kobarg, J. (2019). Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity. World Journal of Biological Chemistry, 10(2), 28.

Bertini Teixeira, M., Figueira, A. C. M., Furlan, A. S., Aquino, B., Alborghetti, M. R., Paes Leme, A. F., ... & Kobarg, J. (2018). Fasciculation and elongation zeta‐1 protein (FEZ1) interacts with the retinoic acid receptor and participates in transcriptional regulation of the Hoxb4 gene. FEBS Open bio, 8(1), 4-14.

Alborghetti, M. R. (2018). Proteínas da família FEZ (Fasciculation and Elongation protein Zeta) como adaptadoras bivalentes do transporte= aspectos funcionais, estruturais e evolutivos (Doctoral dissertation, Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia).

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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