FOXG1

This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]

Full Name

Forkhead Box G1

Function

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

Biological Process

Aging Source: Ensembl
Axon midline choice point recognition Source: Ensembl
Brain development Source: ProtInc
Dorsal/ventral pattern formation Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Neuron fate determination Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of neuroblast proliferation Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Pyramidal neuron migration Source: Ensembl
Regulation of mitotic cell cycle Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Rett syndrome congenital variant (RTTCV):
A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements.