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Rabbit Anti-FOXG1 Monoclonal Antibody (2H7L2) (CBMAB-1277-YC)

Provided herein is a rabbit monoclonal antibody against Human FOXG1. The antibody, clone 2H7L2, can be used for immunoassay techniques, such as ICC, FC and WB.
See all FOXG1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
2H7L2
Antibody Isotype
IgG
Application
ICC, FC, WB

Basic Information

Immunogen
Peptides corresponding to human FOXG1 (aa 742-756, 2-15)
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Forkhead Box G1
Introduction
FOXG1 is a member of the forked-head transcription factor family, which functions as a repressor, may play a role in brain development. Mutations in FOXG1 have been associated with Rett syndrome.
Entrez Gene ID
Human2290
Mouse15228
UniProt ID
HumanP55316
MouseQ60987
Alternative Names
BF1; BF2; QIN; FKH2; HBF2; HFK1; HFK2; HFK3; KHL2; FHKL3; FKHL1; FKHL2; FKHL3; FKHL4; HBF-1; HBF-2; HBF-3; FOXG1A; FOXG1B; FOXG1C; HBF-G2
Function
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
Biological Process
Aging Source: Ensembl
Axon midline choice point recognition Source: Ensembl
Brain development Source: ProtInc
Dorsal/ventral pattern formation Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Neuron fate determination Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of neuroblast proliferation Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Pyramidal neuron migration Source: Ensembl
Regulation of mitotic cell cycle Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Rett syndrome congenital variant (RTTCV):
A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements.

He, Z. H., Zou, S. Y., Li, M., Liao, F. L., Wu, X., Sun, H. Y., ... & Kong, W. J. (2020). The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. Redox biology, 28, 101364.

Zhang, S., Zhang, Y., Dong, Y., Guo, L., Zhang, Z., Shao, B., ... & Chai, R. (2020). Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea. Cellular and molecular life sciences, 77, 1401-1419.

Hou, P. S., HAilin, D. O., Vogel, T., & Hanashima, C. (2020). Transcription and beyond: delineating FOXG1 function in cortical development and disorders. Frontiers in cellular neuroscience, 14, 35.

Ding, Y., Meng, W., Kong, W., He, Z., & Chai, R. (2020). The role of FoxG1 in the inner ear. Frontiers in cell and developmental biology, 8, 614954.

Dai, S., Li, J., Zhang, H., Chen, X., Guo, M., Chen, Z., & Chen, Y. (2020). Structural basis for DNA recognition by FOXG1 and the characterization of disease-causing FOXG1 mutations. Journal of molecular biology, 432(23), 6146-6156.

Hettige, N. C., & Ernst, C. (2019). FOXG1 dose in brain development. Frontiers in pediatrics, 7, 482.

Wong, L. C., Singh, S., Wang, H. P., Hsu, C. J., Hu, S. C., & Lee, W. T. (2019). FOXG1-related syndrome: from clinical to molecular genetics and pathogenic mechanisms. International Journal of Molecular Sciences, 20(17), 4176.

He, Z., Fang, Q., Li, H., Shao, B., Zhang, Y., Zhang, Y., ... & Chai, R. (2019). The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells. Neuropharmacology, 144, 43-57.

Zhu, W., Zhang, B., Li, M., Mo, F., Mi, T., Wu, Y., ... & Hu, B. (2019). Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Nature Communications, 10(1), 928.

Mitter, D., Pringsheim, M., Kaulisch, M., Plümacher, K. S., Schröder, S., Warthemann, R., ... & Brockmann, K. (2018). FOXG1 syndrome: genotype–phenotype association in 83 patients with FOXG1 variants. Genetics in Medicine, 20(1), 98-108.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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