Rabbit Anti-FOXG1 Recombinant Antibody (CBXF-2252) (CBMAB-F1162-CQ)

Name: Rabbit Anti-FOXG1 Recombinant Antibody (CBXF-2252)
SKU: CBMAB-F1162-CQ
Rating: 5 (1 reviews)

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Published Data

Rabbit Anti-FOXG1 Recombinant Antibody (CBXF-2252) (CBMAB-F1162-CQ) in WB

FOXG1 and EFHD2 expression with or without FOXG1/KD in the presence or absence of coclaurine (200 μM) were determined by Western blot and MTT assay, respectively. ...View More

Hu, S. Y., Lin, T. H., Chen, C. Y., He, Y. H., Huang, W. C., Hsieh, C. Y., ... & Chang, W. C. (2024). Stephania tetrandra and its active compound coclaurine sensitize Nsclc cells to cisplatin through Efhd2 inhibition. Pharmaceuticals, 17(10), 1356.

Rabbit Anti-FOXG1 Recombinant Antibody (CBXF-2252) (CBMAB-F1162-CQ) in WB

FOXG1 thermal stability in H1299 cells treated or untreated with coclaurine (200 μM) at the indicated temperatures was determined by Western blot. The relative FOXG1 level (FOXG1/actin) was normalized to the unheated control of each group. ...View More

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-2252

Application

IF, WB, IHC

Immunogen

Synthetic peptide corresponding to residues near the carboxy terminus of human FOXG1 protein.

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IF(ICC)	1:200-1:400
IHC	1:200-1:800

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HEPES & BSA & Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Forkhead Box G1

Introduction

This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome.

Entrez Gene ID

Human	2290
Mouse	15228

UniProt ID

Human	P55316
Mouse	Q60987

Alternative Names

Forkhead Box G1; Brain Factor 1; Brain Factor 2; FOXG1A; FOXG1B; FOXG1C; HBF-2; FKHL1; FKHL2; FKHL3; FKHL4; FKH2; HFK1; HFK2; HFK3; BF1; BF2; Forkhead-Related Protein FKHL1; Forkhead-Related Protein FKHL2; Forkhead-Related Protein FKHL3; Forkhead Box Protein G1A;

Function

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

Biological Process

Aging Source: Ensembl
Axon midline choice point recognition Source: Ensembl
Brain development Source: ProtInc
Dorsal/ventral pattern formation Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Neuron fate determination Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of neuroblast proliferation Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Pyramidal neuron migration Source: Ensembl
Regulation of mitotic cell cycle Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Rett syndrome congenital variant (RTTCV):
A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements.

He, Z. H., Zou, S. Y., Li, M., Liao, F. L., Wu, X., Sun, H. Y., ... & Kong, W. J. (2020). The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. Redox biology, 28, 101364.

Zhang, S., Zhang, Y., Dong, Y., Guo, L., Zhang, Z., Shao, B., ... & Chai, R. (2020). Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea. Cellular and molecular life sciences, 77, 1401-1419.

Hou, P. S., HAilin, D. O., Vogel, T., & Hanashima, C. (2020). Transcription and beyond: delineating FOXG1 function in cortical development and disorders. Frontiers in cellular neuroscience, 14, 35.

Ding, Y., Meng, W., Kong, W., He, Z., & Chai, R. (2020). The role of FoxG1 in the inner ear. Frontiers in cell and developmental biology, 8, 614954.

Dai, S., Li, J., Zhang, H., Chen, X., Guo, M., Chen, Z., & Chen, Y. (2020). Structural basis for DNA recognition by FOXG1 and the characterization of disease-causing FOXG1 mutations. Journal of molecular biology, 432(23), 6146-6156.

Hettige, N. C., & Ernst, C. (2019). FOXG1 dose in brain development. Frontiers in pediatrics, 7, 482.

Wong, L. C., Singh, S., Wang, H. P., Hsu, C. J., Hu, S. C., & Lee, W. T. (2019). FOXG1-related syndrome: from clinical to molecular genetics and pathogenic mechanisms. International Journal of Molecular Sciences, 20(17), 4176.

He, Z., Fang, Q., Li, H., Shao, B., Zhang, Y., Zhang, Y., ... & Chai, R. (2019). The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells. Neuropharmacology, 144, 43-57.

Zhu, W., Zhang, B., Li, M., Mo, F., Mi, T., Wu, Y., ... & Hu, B. (2019). Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Nature Communications, 10(1), 928.

Mitter, D., Pringsheim, M., Kaulisch, M., Plümacher, K. S., Schröder, S., Warthemann, R., ... & Brockmann, K. (2018). FOXG1 syndrome: genotype–phenotype association in 83 patients with FOXG1 variants. Genetics in Medicine, 20(1), 98-108.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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