GLRX3

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Full Name
Glutaredoxin 3
Function
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415).

Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).

Required for hemoglobin maturation (PubMed:23615448).

Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Biological Process
[2Fe-2S] cluster assembly Source: UniProtKB
Cellular iron ion homeostasis Source: GO_Central
Negative regulation of cardiac muscle hypertrophy Source: UniProtKB
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of the force of heart contraction Source: UniProtKB
Cellular Location
Cytosol; Cell cortex; Z line. Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity).
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Anti-GLRX3 antibodies

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Mouse Anti-GLRX3 Recombinant Antibody (CAP843) (CBMAB-AP2559LY)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP843
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-GLRX3 Recombinant Antibody (CBYJT-1289) (CBMAB-T0304-YJ)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1289
Application*: E, WB
Datasheet SDS

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-1308) (CBMAB-G3883-LY)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1308
Application*: WB
Datasheet SDS

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-1306) (CBMAB-G3881-LY)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1306
Application*: E, WB
Datasheet SDS

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-1305) (CBMAB-G3880-LY)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1305
Application*: E
Datasheet SDS

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-131) (CBMAB-G0531-LY)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-131
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-130) (CBMAB-G0530-LY)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-130
Application*: E, WB
Datasheet SDS

Mouse Anti-GLRX3 Recombinant Antibody (791431) (CBMAB-G0529-LY)

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Target: GLRX3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 791431
Application*: WB
Datasheet SDS

GLRX3 Matched Antibody Pair (488) (APMAB-488LY)

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Target: GLRX3
Specificity: Human
Datasheet SDS

GLRX3 Matched Antibody Pair (487) (APMAB-487LY)

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Target: GLRX3
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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