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Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-1305) (CBMAB-G3880-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1305
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant GLRX3 (Val10-Ser117) expressed in E. coli.ImmunogenType: Recombinant protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutaredoxin 3
Introduction
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Entrez Gene ID
10539
UniProt ID
O76003
Alternative Names
Glutaredoxin 3; PKC-Interacting Cousin Of Thioredoxin; PKC-Theta-Interacting Protein; Thioredoxin-Like Protein 2; PKCq-Interacting Protein; Glutaredoxin 4; TXNL2; PICOT;
Function
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415).

Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).

Required for hemoglobin maturation (PubMed:23615448).

Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Biological Process
[2Fe-2S] cluster assembly Source: UniProtKB
Cellular iron ion homeostasis Source: GO_Central
Negative regulation of cardiac muscle hypertrophy Source: UniProtKB
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of the force of heart contraction Source: UniProtKB
Cellular Location
Cytosol; Cell cortex; Z line. Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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