Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-130) (V2LY-1225-LY1522)

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Basic Information

Host Animal
Mouse
Clone
CBLG1-130
Application
WB, IP, IF, IHC
Immunogen
Recombinant GLRX3 (Val10-Ser117).
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
ApplicationNote
WB0.5-2 µg/ml
IF(ICC)5-20 µg/ml
IHC5-20 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, BSA, glycerol
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Glutaredoxin 3
Entrez Gene ID
UniProt ID
Function
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415).

Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).

Required for hemoglobin maturation (PubMed:23615448).

Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Biological Process
[2Fe-2S] cluster assembly Source: UniProtKB
Cellular iron ion homeostasis Source: GO_Central
Negative regulation of cardiac muscle hypertrophy Source: UniProtKB
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of the force of heart contraction Source: UniProtKB
Cellular Location
Cytosol; Cell cortex; Z line. Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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