Mouse Anti-GLRX3 Recombinant Antibody (791431) (CBMAB-G0529-LY)

Name: Mouse Anti-GLRX3 Recombinant Antibody (791431)
SKU: CBMAB-G0529-LY
Rating: 5 (1 reviews)

See all GLRX3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

791431

Application

Immunogen

E. coli-derived recombinant human Glutaredoxin 3/GLRX3, Asn126-Lys294, Accession # O76003

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

lyophilized

Buffer

Trehalose

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glutaredoxin 3

Introduction

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Entrez Gene ID

10539

UniProt ID

O76003

Alternative Names

Glutaredoxin 3; PKC-Interacting Cousin Of Thioredoxin; PKC-Theta-Interacting Protein; Thioredoxin-Like Protein 2; PKCq-Interacting Protein; Glutaredoxin 4; TXNL2; PICOT;

Function

Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415).

Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).

Required for hemoglobin maturation (PubMed:23615448).

Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

Biological Process

[2Fe-2S] cluster assembly Source: UniProtKB
Cellular iron ion homeostasis Source: GO_Central
Negative regulation of cardiac muscle hypertrophy Source: UniProtKB
Protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Regulation of the force of heart contraction Source: UniProtKB

Cellular Location

Cytosol; Cell cortex; Z line. Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-GLRX3 Recombinant Antibody (791431)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GLRX3 Matched Antibody Pair (487) (CAT#: APMAB-487LY)

GLRX3 Matched Antibody Pair (488) (CAT#: APMAB-488LY)

Related Products

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-130) (CAT#: CBMAB-G0530-LY)

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-131) (CAT#: CBMAB-G0531-LY)

Mouse Anti-GLRX3 Recombinant Antibody (CAP843) (CAT#: CBMAB-AP2559LY)

Mouse Anti-GLRX3 Recombinant Antibody (CBYJT-1289) (CAT#: CBMAB-T0304-YJ)

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-1305) (CAT#: CBMAB-G3880-LY)

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-1308) (CAT#: CBMAB-G3883-LY)

GLRX3 Matched Antibody Pair (488) (CAT#: APMAB-488LY)

Mouse Anti-GLRX3 Recombinant Antibody (CBLG1-1306) (CAT#: CBMAB-G3881-LY)

GLRX3 Matched Antibody Pair (487) (CAT#: APMAB-487LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry