GMDS

GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).

Full Name

GDP-mannose 4, 6-dehydratase

Function

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.

Biological Process

de novo' GDP-L-fucose biosynthetic process Source: UniProtKB
GDP-mannose metabolic process Source: UniProtKB
Notch signaling pathway Source: UniProtKB

Cellular Location

Cytosol; Extracellular exosome; Cytoplasm

Anti-GMDS antibodies

Mouse Anti-GMDS Recombinant Antibody (CBLG1-2834) (CBMAB-G4000-LY)

Datasheet

SDS

Target: GMDS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2834

Application*: IP, IC/IF

Mouse Anti-GMDS Recombinant Antibody (CBLG1-3192) (CBMAB-G4001-LY)

Datasheet

SDS

Target: GMDS

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3192

Application*: WB

Mouse Anti-GMDS Recombinant Antibody (CBLG1-2835) (CBMAB-G4002-LY)

Datasheet

SDS

Target: GMDS

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLG1-2835

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)