GPR18

G protein-coupled receptor 18

Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937).

However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161).

Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058).

The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083).

May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity).

Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity).

Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).

CD8-positive, alpha-beta intraepithelial T cell differentiation Source: Ensembl
CD8-positive, gamma-delta intraepithelial T cell differentiation Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of leukocyte chemotaxis Source: Ensembl
Negative regulation of tumor necrosis factor production Source: Ensembl
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of Rho protein signal transduction Source: GO_Central

Cell membrane; Cytoplasmic vesicle membrane

Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-56
Helical: 57-77
Extracellular: 78-95
Helical: 96-116
Cytoplasmic: 117-138
Helical: 139-159
Extracellular: 160-191
Helical: 192-212
Cytoplasmic: 213-232
Helical: 233-253
Extracellular: 254-268
Helical: 269-289
Cytoplasmic: 290-331