GRIPAP1

This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function.

GRIP1 associated protein 1

Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).

GRASP-1 C-terminal chain:
Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.

Neurotransmitter receptor transport, endosome to postsynaptic membrane Source: GO_Central
Regulation of modification of synaptic structure Source: GO_Central
Regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane Source: GO_Central
Regulation of recycling endosome localization within postsynapse Source: GO_Central

Early endosome membrane; Recycling endosome membrane; Axon; Dendrite; Synapse. Localizes to recycling endosomal tubules that are emanating from early endosomes.

Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.