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Mouse Anti-GRIPAP1 Recombinant Antibody (2C11) (CBMAB-G4973-LY)

This product is antibody recognizes GRIPAP1. The antibody 2C11 immunoassay techniques such as: FC.
See all GRIPAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C11
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Full length human recombinant protein of human GRIPAP1 (NP_064522) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GRIP1 associated protein 1
Introduction
This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]
Entrez Gene ID
56850
UniProt ID
Q4V328
Alternative Names
GRIP1 Associated Protein 1; GRASP-1; GRIP1-Associated Protein 1; KIAA1167;
Function
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).

GRASP-1 C-terminal chain:
Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
Biological Process
Neurotransmitter receptor transport, endosome to postsynaptic membrane Source: GO_Central
Regulation of modification of synaptic structure Source: GO_Central
Regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane Source: GO_Central
Regulation of recycling endosome localization within postsynapse Source: GO_Central
Cellular Location
Early endosome membrane; Recycling endosome membrane; Axon; Dendrite; Synapse. Localizes to recycling endosomal tubules that are emanating from early endosomes.
PTM
Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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