GUCA1B

The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa.
Full Name
guanylate cyclase activator 1B (retina)
Function
Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity).

This Ca2+-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).

May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).
Biological Process
Body fluid secretion Source: ProtInc
Cell-cell signaling Source: ProtInc
Receptor guanylyl cyclase signaling pathway Source: ProtInc
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane; Photoreceptor inner segment; Photoreceptor outer segment. Subcellular location is not affected by light or dark conditions.
Involvement in disease
Retinitis pigmentosa 48 (RP48):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
PTM
The N-terminus is blocked.
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Anti-GUCA1B antibodies

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Mouse Anti-GUCA1B Recombinant Antibody (CBFYH-3323) (CBMAB-H0063-FY)

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Target: GUCA1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: CBFYH-3323
Application*: WB, E, IH, P
Datasheet SDS

Mouse Anti-GUCA1B Recombinant Antibody (CBLG1-2139) (CBMAB-G5765-LY)

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Target: GUCA1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: CBLG1-2139
Application*: E, WB
Datasheet SDS

Rabbit Anti-GUCA1B Recombinant Antibody (CBLG1-3044) (CBMAB-G5763-LY)

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Target: GUCA1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBLG1-3044
Application*: WB
Datasheet SDS

Mouse Anti-GUCA1B Recombinant Antibody (6D433) (CBMAB-G5761-LY)

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Target: GUCA1B
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle
Clone: 6D433
Application*: WB
Datasheet SDS

Mouse Anti-GUCA1B Recombinant Antibody (5E7) (CBMAB-G5759-LY)

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Target: GUCA1B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5E7
Application*: E, WB
Datasheet SDS

Mouse Anti-GUCA1B Monoclonal Antibody (A1) (CBMAB-1325-YC)

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Target: GUCA1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: A1
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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