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Mouse Anti-GUCA1B Monoclonal Antibody (A1) (CBMAB-1325-YC)


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Summary

Host Animal
Mouse
Specificity
Cattle
Clone
A1
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Bacterial expressed full length GCAP2.
Specificity
Cattle
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
guanylate cyclase activator 1B (retina)
Introduction
GUCA1B is a calcium-binding protein that activates photoreceptor guanylate cyclases. Mutations in GUCA1B gene can cause a form of retinitis pigmentosa.
Entrez Gene ID
286851
UniProt ID
P51177
Alternative Names
GCAP2
Function
Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity).

This Ca2+-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).

May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).
Biological Process
Body fluid secretion Source: ProtInc
Cell-cell signaling Source: ProtInc
Receptor guanylyl cyclase signaling pathway Source: ProtInc
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane; Photoreceptor inner segment; Photoreceptor outer segment. Subcellular location is not affected by light or dark conditions.
Involvement in disease
Retinitis pigmentosa 48 (RP48):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
PTM
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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