• Home
  • GUCA1B
  • Rabbit Anti-GUCA1B Recombinant Antibody (CBLG1-3044)

Rabbit Anti-GUCA1B Recombinant Antibody (CBLG1-3044) (CBMAB-G5763-LY)

See all GUCA1B antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
CBLG1-3044
Application
WB
Specificity
Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.021 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
guanylate cyclase activator 1B (retina)
Introduction
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Entrez Gene ID
Mouse107477
Rat316218
UniProt ID
MouseQ8VBV8
RatD3ZID7
Function
Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity).

This Ca2+-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).

May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).
Biological Process
Body fluid secretion Source: ProtInc
Cell-cell signaling Source: ProtInc
Receptor guanylyl cyclase signaling pathway Source: ProtInc
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane; Photoreceptor inner segment; Photoreceptor outer segment. Subcellular location is not affected by light or dark conditions.
Involvement in disease
Retinitis pigmentosa 48 (RP48):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
PTM
The N-terminus is blocked.

Zahid, S., Branham, K., Schlegel, D., Pennesi, M. E., Michaelides, M., Heckenlively, J., ... & Jayasundera, T. (2018). GUCA1B. Retinal Dystrophy Gene Atlas, 113-113.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-GUCA1B Recombinant Antibody (CBLG1-3044)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-GUCA1B Recombinant Antibody (6D433) (CAT#: CBMAB-G5761-LY)

Mouse Anti-GUCA1B Recombinant Antibody (5E7) (CAT#: CBMAB-G5759-LY)

Mouse Anti-GUCA1B Recombinant Antibody (CBFYH-3323) (CAT#: CBMAB-H0063-FY)

Mouse Anti-GUCA1B Monoclonal Antibody (A1) (CAT#: CBMAB-1325-YC)

Mouse Anti-GUCA1B Recombinant Antibody (CBLG1-2139) (CAT#: CBMAB-G5765-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry