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Rabbit Anti-GUCA1B Recombinant Antibody (CBLG1-3044) (CBMAB-G5763-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
CBLG1-3044
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.021 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
guanylate cyclase activator 1B (retina)
Introduction
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Entrez Gene ID
Mouse107477
Rat316218
UniProt ID
MouseQ8VBV8
RatD3ZID7
Function
Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity).

This Ca2+-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).

May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).
Biological Process
Body fluid secretion Source: ProtInc
Cell-cell signaling Source: ProtInc
Receptor guanylyl cyclase signaling pathway Source: ProtInc
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane; Photoreceptor inner segment; Photoreceptor outer segment. Subcellular location is not affected by light or dark conditions.
Involvement in disease
Retinitis pigmentosa 48 (RP48):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
PTM
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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