KDM5C/Jarid1C/SMCX

KDM5C/Jarid1C/SMCX

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558).
Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Response to toxic substanceIEA:Ensembl
Rhythmic processIEA:UniProtKB-KW

Nucleus

Intellectual developmental disorder, X-linked, syndromic, Claes-Jensen type (MRXSCJ):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSCJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.