MAD2L1BP

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

MAD2L1 binding protein

May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.

Deactivation of mitotic spindle assembly checkpointManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of exit from mitosisManual Assertion Based On ExperimentIMP:UniProtKB

Nucleus
Cytoplasm, cytoskeleton, spindle
During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.