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Mouse Anti-MAD2L1BP Recombinant Antibody (4G11) (CBMAB-A5148-LY)

The product is antibody recognizes MAD2L1BP. The antibody 4G11 immunoassay techniques such as: IP, ELISA.
See all MAD2L1BP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G11
Antibody Isotype
IgG2a, κ
Application
IP, ELISA

Basic Information

Immunogen
MAD2L1BP (NP_055443.1, 171 a.a. ~ 274 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MAD2L1 binding protein
Introduction
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
Entrez Gene ID
9587
UniProt ID
Q15013
Alternative Names
CMT2; KIAA0110; MGC11282; RP1-261G23.6
Function
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
Biological Process
Deactivation of mitotic spindle assembly checkpointManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of exit from mitosisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Cytoplasm, cytoskeleton, spindle
During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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