NUDT5

Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999 [PubMed 10373642]).[supplied by OMIM

nudix (nucleoside diphosphate linked moiety X)-type motif 5

Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257).
In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728).
Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046).
In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257).
Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Does not play a role in U8 snoRNA decapping activity (By similarity).
Binds U8 snoRNA (By similarity).

ATP generation from poly-ADP-D-riboseManual Assertion Based On ExperimentIDA:UniProtKB
Chromatin remodelingManual Assertion Based On ExperimentIDA:UniProtKB
D-ribose catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Nucleobase-containing small molecule metabolic processTAS:Reactome
Nucleoside phosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Nucleotide metabolic process1 PublicationNAS:ProtInc
Ribonucleoside diphosphate catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Ribose phosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Nucleus

Phosphorylation at Thr-45 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity.