NUF2

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.

NUF2, NDC80 Kinetochore Complex Component

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Attachment of mitotic spindle microtubules to kinetochoreManual Assertion Based On ExperimentIBA:GO_Central
Attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIDA:ComplexPortal
Cell divisionIEA:UniProtKB-KW
Chromosome segregation1 PublicationNAS:UniProtKB
Kinetochore organizationManual Assertion Based On ExperimentIBA:GO_Central
Meiotic chromosome segregationManual Assertion Based On ExperimentIBA:GO_Central
Mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal
Mitotic spindle organizationManual Assertion Based On ExperimentIBA:GO_Central

Nucleus
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.

Can be phosphorylated by AURKA and AURKB.