PGLYRP1

PGLYRP1 has restricted expression toward bone marrow (RPKM 135.5).

Full Name

Peptidoglycan Recognition Protein 1

Function

Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:9707603).
Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed:21247889, PubMed:26183779).
In addition, acts in complex with the Ca2+-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement (PubMed:26654597).
Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system (PubMed:30713770).
Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity (PubMed:29083508, PubMed:28977785).
Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (PubMed:28977785, PubMed:25595774).

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Involved in interaction with hostIEA:Ensembl
Response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Detection of bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune response1 PublicationNAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of interferon-gamma productionIEA:Ensembl
Negative regulation of natural killer cell differentiation involved in immune responseIEA:Ensembl
Peptidoglycan catabolic processIEA:InterPro

Cellular Location

Secreted
Cytoplasmic granule

PTM

N-glycosylated. N-glycosylation is required for bactericidal activity.