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Mouse Anti-PGLYRP1 Recombinant Antibody (45G1) (CBMAB-P1585-YC)

Provided herein is a Mouse monoclonal antibody against Human Peptidoglycan Recognition Protein 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PGLYRP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
45G1
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Peptidoglycan Recognition Protein 1
Introduction
PGLYRP1 has restricted expression toward bone marrow (RPKM 135.5).
Entrez Gene ID
UniProt ID
Alternative Names
Peptidoglycan Recognition Protein 1; TNFSF3L; PGLYRP; PGRP-S; PGRP; TNF Superfamily, Member 3 (LTB)-Like (Peptidoglycan Recognition Protein);
Function
Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:9707603).
Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed:21247889, PubMed:26183779).
In addition, acts in complex with the Ca2+-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement (PubMed:26654597).
Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system (PubMed:30713770).
Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity (PubMed:29083508, PubMed:28977785).
Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (PubMed:28977785, PubMed:25595774).
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Involved in interaction with hostIEA:Ensembl
Response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Detection of bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune response1 PublicationNAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of interferon-gamma productionIEA:Ensembl
Negative regulation of natural killer cell differentiation involved in immune responseIEA:Ensembl
Peptidoglycan catabolic processIEA:InterPro
Cellular Location
Secreted
Cytoplasmic granule
PTM
N-glycosylated. N-glycosylation is required for bactericidal activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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