Human Recombinant PGLYRP1 protein, Biotin Conjugated, His Tag (V2LY-0526-LY6138)

Name: Human Recombinant PGLYRP1 protein, Biotin Conjugated, His Tag
SKU: V2LY-0526-LY6138
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant PGLYRP1 protein, Biotin Conjugated, His Tag consist of Amino Acid: 1-196 and predicts a molecular mass of 20.88 kDa.

Molecule Mass

20.88 kDa

Conjugates

Biotin

Sequence

Amino Acid: 1-196

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Peptidoglycan Recognition Protein 1

Function

Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:9707603).
Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed:21247889, PubMed:26183779).
In addition, acts in complex with the Ca2+-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement (PubMed:26654597).
Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system (PubMed:30713770).
Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity (PubMed:29083508, PubMed:28977785).
Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (PubMed:28977785, PubMed:25595774).

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Involved in interaction with hostIEA:Ensembl
Response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Detection of bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune response1 PublicationNAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of inflammatory responseIEA:Ensembl
Negative regulation of interferon-gamma productionIEA:Ensembl
Negative regulation of natural killer cell differentiation involved in immune responseIEA:Ensembl
Peptidoglycan catabolic processIEA:InterPro

Cellular Location

Secreted
Cytoplasmic granule

PTM

N-glycosylated. N-glycosylation is required for bactericidal activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PGLYRP1 protein, His Tag (CAT#: V2LY-0526-LY6139)

Mouse Recombinant PGLYRP1 protein, His Tag (CAT#: V2LY-0526-LY8774)

Cattle PGLYRP1 ELISA Kit (CAT#: V2LY-0626-LY2781)

Human PGLYRP1 ELISA Kit (CAT#: V2LY-0626-LY5002)

Related Products

Human Recombinant PGLYRP1 protein, His Tag (CAT#: V2LY-0526-LY6139)

Mouse Anti-PGLYRP1 Recombinant Antibody (45G1) (CAT#: CBMAB-P1585-YC)

Cattle PGLYRP1 ELISA Kit (CAT#: V2LY-0626-LY2781)

Human PGLYRP1 ELISA Kit (CAT#: V2LY-0626-LY5002)

Mouse Recombinant PGLYRP1 protein, His Tag (CAT#: V2LY-0526-LY8774)

Mouse Anti-PGLYRP1 Recombinant Antibody (188C424) (CAT#: CBMAB-1666-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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