Phospho-NR4A1 (Ser351)

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Nuclear Receptor Subfamily 4 Group A Member 1

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity).
May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).

Apoptotic processIEA:Ensembl
Cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to corticotropin-releasing hormone stimulusISS:UniProtKB
Cellular response to fibroblast growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to vascular endothelial growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Endothelial cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Fat cell differentiationISS:UniProtKB
Negative regulation of cell cycleISS:UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA:Ensembl
Neurotransmitter secretion involved in regulation of skeletal muscle contractionIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of type B pancreatic cell proliferationISS:UniProtKB
Response to amphetamineIEA:Ensembl
Response to electrical stimulusIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skeletal muscle cell differentiationIEA:Ensembl

Nucleus
Cytoplasm
Mitochondrion
Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340).
Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950).

Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.