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Rabbit Anti-Phospho-NR4A1 (Ser351) Recombinant Antibody (D22G5) (CBMAB-CP1784-LY)

The product is antibody recognizes Phospho-NR4A1 (Ser351). The antibody D22G5 immunoassay techniques such as: WB.
See all Phospho-NR4A1 (Ser351) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D22G5
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser351 of human Nur77 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nuclear Receptor Subfamily 4 Group A Member 1
Introduction
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Entrez Gene ID
Human3164
Mouse15370
Rat79240
UniProt ID
HumanP22736
MouseP12813
RatP22829
Alternative Names
Nuclear Receptor Subfamily 4 Group A Member 1; Nuclear Hormone Receptor NUR/77; Early Response Protein NAK1; Orphan Nuclear Receptor HMR; Orphan Nuclear Receptor TR3; Testicular Receptor 3; NUR77; GFRP1; ST-59; HMR; Nerve Growth Factor IB Nuclear Receptor Variant 1; Nuclear Receptor Subfamily 4; Group A; Member 1;
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity).
May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).
Biological Process
Apoptotic processIEA:Ensembl
Cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to corticotropin-releasing hormone stimulusISS:UniProtKB
Cellular response to fibroblast growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to vascular endothelial growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Endothelial cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Fat cell differentiationISS:UniProtKB
Negative regulation of cell cycleISS:UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA:Ensembl
Neurotransmitter secretion involved in regulation of skeletal muscle contractionIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of type B pancreatic cell proliferationISS:UniProtKB
Response to amphetamineIEA:Ensembl
Response to electrical stimulusIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Skeletal muscle cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Mitochondrion
Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340).
Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950).
PTM
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.
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For research use only. Not intended for any clinical use.

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