PNN

PNN (Pinin, Desmosome Associated Protein) is a protein coding gene. Diseases associated with PNN include Premenstrual Tension and Epileptic Encephalopathy, Childhood-Onset. Among its related pathways are RNA transport and mRNA surveillance pathway. Gene Ontology annotations related to this gene include structural molecule activity.

pinin, desmosome associated protein

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.

Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
mRNA splicing, via spliceosome1 PublicationIC:UniProtKB

Nucleus speckle
Cell junction, desmosome
Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.