PPIF

PPIF (Peptidylprolyl Isomerase F) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Toxoplasmosis. Gene Ontology (GO) annotations related to this gene include peptide binding and cyclosporin A binding. An important paralog of this gene is PPIA.

Peptidylprolyl Isomerase F

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357).
Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735).
It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735).
In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440).
Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity).
Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691).

Apoptotic mitochondrial changesIEA:Ensembl
Cellular response to arsenic-containing substanceISS:UniProtKB
Cellular response to calcium ionISS:UniProtKB
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial outer membrane permeabilization involved in programmed cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Necroptotic processIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of ATP-dependent activityISS:UniProtKB
Negative regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of oxidative phosphorylationISS:UniProtKB
Negative regulation of oxidative phosphorylation uncoupler activityISS:UniProtKB
Negative regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of release of cytochrome c from mitochondriaISS:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitochondrial membrane permeabilityManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of mitochondrial membrane permeability involved in programmed necrotic cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of necrotic cell deathIEA:Ensembl
Regulation of proton-transporting ATPase activity, rotational mechanismISS:UniProtKB
Response to ischemiaISS:UniProtKB

Mitochondrion matrix

Acetylated at Lys-167; deacetylated at Lys-167 by SIRT3.