PPP1R1A

PPP1R1A (Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A) is a protein coding gene. Diseases associated with PPP1R1A include Rosette-Forming Glioneuronal Tumor. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling and Activation of cAMP-Dependent PKA. Gene Ontology annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of the gene isPPP1R1C.

Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

Glycogen metabolic processIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm

Phosphorylation of Thr-35 is required for activity.