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Rabbit Anti-PPP1R1A Recombinant Antibody (CBYC-P569) (CBMAB-P2610-YC)

Provided herein is a Rabbit monoclonal antibody against Human Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A. The antibody can be used for immunoassay techniques, such as WB, IP, FC, ICC, IF, IHC-P.
See all PPP1R1A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYC-P569
Antibody Isotype
IgG
Application
WB, IP, FC, ICC, IF, IHC-P

Basic Information

Immunogen
A synthetic peptide corresponding to residues in the N-terminus of human IPP-1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, 0.01% sodium azide, 50% glycerol, 0.05% BSA
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A
Introduction
PPP1R1A (Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A) is a protein coding gene. Diseases associated with PPP1R1A include Rosette-Forming Glioneuronal Tumor. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling and Activation of cAMP-Dependent PKA. Gene Ontology annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of the gene isPPP1R1C.
Entrez Gene ID
Human5502
Mouse58200
Rat58977
UniProt ID
HumanQ13522
MouseQ9ERT9
RatP19103
Alternative Names
I1; IPP1
Function
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Biological Process
Glycogen metabolic processIEA:UniProtKB-KW
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Phosphorylation of Thr-35 is required for activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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