RAE1

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

RIBONUCLEIC ACID EXPORT 1

Acts as mRNA export factor involved in nucleocytoplasmic transport (PubMed:33849972, PubMed:20498086).
Plays a role in mitotic bipolar spindle formation (PubMed:17172455).
May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455).

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process cellular response to organic cyclic compoundIEA:Ensembl
Biological Process mRNA export from nucleusManual Assertion Based On ExperimentTAS:ProtInc
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process regulation of mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transcription-dependent tethering of RNA polymerase II gene DNA at nuclear peripheryManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle pole
Nucleus envelope
Recruited from interphase nuclei to spindle MTs during mitosis.