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Rat Anti-RAE1 Recombinant Antibody (186107) (CBMAB-R0070-CN)

This product is a Rat antibody that recognizes RAE1. The antibody 186107 can be used for immunoassay techniques such as: FC.
See all RAE1 antibodies
Published Data
Fig.1 Representative flow cytometry plots of NKG2D ligand expression on splenic B cells.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
186107
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Recombinant protein corresponding to aa. 29-227 from mouse Rae-1, NS0-derived (UniProt # Q9JI58)
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.5% BSA
Preservative
0.09% Sodium azide

Target

Full Name
RIBONUCLEIC ACID EXPORT 1
Introduction
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
66679
UniProt ID
Q8C570
Alternative Names
Ribonucleic Acid Export 1; Rae1 Protein Homolog; MRNP41; Homolog Of Yeast Rae1 (Bharathi) MRNA-Associated Protein Of 41 KDa (Kraemer); RAE1 (RNA Export 1, S.Pombe) Homolog; RAE1 RNA Export 1 Homolog (S. Pombe); MRNA-Associated Protein MRNP 41; MRNA-Associated Protein Mrnp 41; MRNA-Binding Protein, 41-KD;
Function
Acts as mRNA export factor involved in nucleocytoplasmic transport (PubMed:33849972, PubMed:20498086).
Plays a role in mitotic bipolar spindle formation (PubMed:17172455).
May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455).
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process cellular response to organic cyclic compoundIEA:Ensembl
Biological Process mRNA export from nucleusManual Assertion Based On ExperimentTAS:ProtInc
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process regulation of mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transcription-dependent tethering of RNA polymerase II gene DNA at nuclear peripheryManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle pole
Nucleus envelope
Recruited from interphase nuclei to spindle MTs during mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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