RTN4RL2

RTN4RL2 (Reticulon 4 Receptor Like 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is RTN4RL1.

Reticulon 4 Receptor Like 2

Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity).
Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity).
Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).

Biological Process axon regenerationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process cell surface receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of neuron projection developmentISS:UniProtKB

Cell membrane
Membrane raft
Cell projection, dendrite
Perikaryon
Cell projection, axon
Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses.

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.
N-glycosylated.