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Rabbit Anti-RTN4RL2 Recombinant Antibody (P14) (CBMAB-N0594-WJ)

This product is a Rabbit antibody that recognizes RTN4RL2. The antibody P14 can be used for immunoassay techniques such as: WB, FC, ELISA, IP, CyTOF.
See all RTN4RL2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
P14
Antibody Isotype
IgG
Application
WB, FC, ELISA, IP, CyTOF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Reticulon 4 Receptor Like 2
Introduction
RTN4RL2 (Reticulon 4 Receptor Like 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is RTN4RL1.
Entrez Gene ID
Human349667
Mouse269295
Rat311169
UniProt ID
HumanQ86UN3
MouseQ7M6Z0
RatQ80WD1
Alternative Names
Reticulon 4 Receptor Like 2; Nogo-66 Receptor-Related Protein 2; Nogo-66 Receptor Homolog 1; Nogo Receptor-Like 3; NGRH1; NgR2; Reticulon-4 Receptor-Like 2; NGRL3;
Function
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity).
Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity).
Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Biological Process
Biological Process axon regenerationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process cell surface receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of neuron projection developmentISS:UniProtKB
Cellular Location
Cell membrane
Membrane raft
Cell projection, dendrite
Perikaryon
Cell projection, axon
Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses.
PTM
Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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