S. cerevisiae Sir3

Saccharomyces cerevisiae is a species of yeast. It has been instrumental to winemaking, baking, and brewing since ancient times. It is believed to have been originally isolated from the skin of grapes. It is one of the most intensively studied eukaryotic model organisms in molecular and cell biology, much like Escherichia coli as the model bacterium. It is the microorganism behind the most common type of fermentation. S. cerevisiae cells are round to ovoid, 5–10 μm in diameter. It reproduces by a division process known as budding.

Full Name

Saccharomyces cerevisiae Sir3

Function

The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.

Biological Process

Biological Process double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:SGD
Biological Process establishment of protein-containing complex localization to telomereManual Assertion Based On ExperimentIMP:SGD
Biological Process heterochromatin assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process nuclear-transcribed mRNA catabolic process, non-stop decayManual Assertion Based On ExperimentIMP:SGD
Biological Process silent mating-type cassette heterochromatin assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process subtelomeric heterochromatin assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process telomere tethering at nuclear peripheryManual Assertion Based On ExperimentIMP:SGD

Cellular Location

Nucleus

PTM

N-terminal acetylation by NatA is important for transcriptional silencing activity.