Mouse Anti-S. cerevisiae Sir3 Recombinant Antibody (CBMJV-0376) (CBMAB-V208-0395-WJ)

See all S. cerevisiae Sir3 antibodies
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Basic Information

Host Animal
Mouse
Clone
CBMJV-0376
Application
WB, ELISA
Specificity
S. cerevisiae
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Saccharomyces cerevisiae Sir3
Introduction
Saccharomyces cerevisiae is a species of yeast. It has been instrumental to winemaking, baking, and brewing since ancient times. It is believed to have been originally isolated from the skin of grapes. It is one of the most intensively studied eukaryotic model organisms in molecular and cell biology, much like Escherichia coli as the model bacterium. It is the microorganism behind the most common type of fermentation. S. cerevisiae cells are round to ovoid, 5–10 μm in diameter. It reproduces by a division process known as budding.
Alternative Names
S. cerevisiae Sir3; Saccharomyces cerevisiae Sir3
Function
The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
Biological Process
Biological Process double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:SGD
Biological Process establishment of protein-containing complex localization to telomereManual Assertion Based On ExperimentIMP:SGD
Biological Process heterochromatin assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process nuclear-transcribed mRNA catabolic process, non-stop decayManual Assertion Based On ExperimentIMP:SGD
Biological Process silent mating-type cassette heterochromatin assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process subtelomeric heterochromatin assemblyManual Assertion Based On ExperimentIMP:SGD
Biological Process telomere tethering at nuclear peripheryManual Assertion Based On ExperimentIMP:SGD
Cellular Location
Nucleus
PTM
N-terminal acetylation by NatA is important for transcriptional silencing activity.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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