SAMSN1

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM

Full Name

SAM domain, SH3 domain and nuclear localization signals 1

Function

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).

Biological Process

Biological Process negative regulation of adaptive immune responseISS:UniProtKB
Biological Process negative regulation of B cell activationISS:UniProtKB
Biological Process negative regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB

Cellular Location

Nucleus
Cytoplasm
Cell projection, ruffle
Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity).

Anti-SAMSN1 antibodies

Mouse Anti-SAMSN1 Recombinant Antibody (CBXS-5877) (CBMAB-S0728-CQ)

Datasheet

SDS

Target: SAMSN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5877

Application*: WB, IH

Mouse Anti-SAMSN1 Recombinant Antibody (CBXS-4512) (CBMAB-S1753-CQ)

Datasheet

SDS

Target: SAMSN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4512

Application*: WB

Mouse Anti-SAMSN1 Recombinant Antibody (CBXS-2848) (CBMAB-S5598-CQ)

Datasheet

SDS

Target: SAMSN1

Host: Mouse

Specificity: Human

Clone: CBXS-2848

Application*: E

Mouse Anti-SAMSN1 Recombinant Antibody (CBXS-2701) (CBMAB-S5453-CQ)

Datasheet

SDS

Target: SAMSN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-2701

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)