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Mouse Anti-SAMSN1 Recombinant Antibody (CBXS-5877) (CBMAB-S0728-CQ)

This product is a mouse antibody that recognizes SAMSN1. The antibody CBXS-5877 can be used for immunoassay techniques such as: WB, IHC.
See all SAMSN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5877
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-250 of human SAMSN1(NP_071419)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SAM domain, SH3 domain and nuclear localization signals 1
Introduction
SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).
Entrez Gene ID
64092
UniProt ID
Q9NSI8
Alternative Names
SAM Domain, SH3 Domain And Nuclear Localization Signals 1; Src Homology Domain 3 (SH3)-Containing Adapter Protein SH3 Lymphocyte Protein 2; SAM Domain, SH3 Domain And Nuclear Localization Signals Protein 1; Nuclear Localization Signals, SAM And SH3 Domain Containing 1; Hematopoietic Adaptor Containing SH3 And SAM Domains 1; SAM And SH3 Domain Containing 2; SH3-SAM Adaptor Protein; NASH1; HACS1;
Function
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).
Biological Process
Biological Process negative regulation of adaptive immune responseISS:UniProtKB
Biological Process negative regulation of B cell activationISS:UniProtKB
Biological Process negative regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cell projection, ruffle
Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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