SARS-CoV 7a

The SARS coronavirus, sometimes shortened to SARS-CoV, is the virus that causes severe acute respiratory syndrome (SARS). On April 16, 2003, following the outbreak of SARS in Asia and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that the coronavirus identified by a number of laboratories was the official cause of SARS. Samples of the virus are being held in laboratories in New York City, San Francisco, Manila, Hong Kong, and Toronto.

SARS coronavirus 7a Protein

Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 thereby interfering with its glycosylation. May suppress small interfering RNA (siRNA). May bind to host ITGAL, thereby playing a role in attachment or modulation of leukocytes.

Biological Process induction by virus of host apoptotic processManual Assertion Based On ExperimentIDA:DIBU
Biological Process modulation by virus of host G0/G1 transition checkpointIEA:UniProtKB-KW
Biological Process suppression by virus of host tetherin activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process suppression by virus of host type I interferon-mediated signaling pathwayIEA:UniProtKB-KW

Virion
Host endoplasmic reticulum membrane
Host endoplasmic reticulum-Golgi intermediate compartment membrane
Host Golgi apparatus membrane

Virion surface: 16-96
Helical: 97-117
Intravirion: 118-122