SARS-CoV E2

The SARS coronavirus, sometimes shortened to SARS-CoV, is the virus that causes severe acute respiratory syndrome (SARS). On April 16, 2003, following the outbreak of SARS in Asia and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that the coronavirus identified by a number of laboratories was the official cause of SARS. Samples of the virus are being held in laboratories in New York City, San Francisco, Manila, Hong Kong, and Toronto.

SARS coronavirus E2 glycoprotein precursor

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity).
Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

Biological Process disruption by virus of host cell membraneManual Assertion Based On ExperimentIDA:CACAO
Biological Process pore formation by virus in membrane of host cellIEA:InterPro
Biological Process viral budding from Golgi membraneManual Assertion Based On ExperimentIDA:UniProtKB

Host endoplasmic reticulum-Golgi intermediate compartment
Host Golgi apparatus membrane
Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment (PubMed:20861307).
The cytoplasmic tail functions as a Golgi complex-targeting signal.

Virion surface: 1-16
Helical: 17-37
Intravirion: 38-76