SELENOM

The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.

Selenoprotein M

May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Biological Process adipose tissue developmentIEA:Ensembl
Biological Process corticosterone secretionIEA:Ensembl
Biological Process hormone metabolic processIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process response to selenium ionIEA:Ensembl

Cytoplasm, perinuclear region
Endoplasmic reticulum
Golgi apparatus
Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.