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SHBG

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
sex hormone-binding globulin
Function
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Cellular Location
Secreted
In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
PTM
Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.

Anti-SHBG antibodies

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Target: SHBG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-A1048
Application*: WB, IC, P, C, E
Target: SHBG
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-A1049
Application*: WB, IC, P, C, E
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SHBG/245
Application*: F, P, IF, MC
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5589
Application*: E, R
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5596
Application*: E
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5901
Application*: WB, E, C
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3825
Application*: P, WB
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3958
Application*: P, WB
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4074
Application*: WB
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4160
Application*: WB
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4205
Application*: WB, IH
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4683
Application*: E
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-5168
Application*: E, P, WB
Target: SHBG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1554
Application*: WB, P
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1783
Application*: WB
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-2314
Application*: WB
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2382
Application*: E, WB
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-2383
Application*: E, WB
Target: SHBG
Host: Mouse
Specificity: Rat
Clone: CBXS-2505
Application*: E, IC, IH, WB
Target: SHBG
Host: Mouse
Specificity: Human
Clone: CBXS-2656
Application*: E
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SPM605
Application*: F, P, IF
Target: SHBG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TTEB3
Application*: IF, P
Target: SHBG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5E6
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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