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Mouse Anti-SHBG Recombinant Antibody (SHBG/245) (CBMAB-S0186-CQ)

This product is a mouse antibody that recognizes SHBG. The antibody SHBG/245 can be used for immunoassay techniques such as: FC, IHC-P, IF, CyTOF.
See all SHBG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
SHBG/245
Antibody Isotype
IgG1
Application
FC, IHC-P, IF, CyTOF

Basic Information

Immunogen
Recombinant Full length human SHBG protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sex hormone-binding globulin
Introduction
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
6462
UniProt ID
P04278
Alternative Names
Sex Hormone Binding Globulin; Testis-Specific Androgen-Binding Protein; Testosterone-Estradiol-Binding Globulin; Testosterone-Estrogen-Binding Globulin; Sex Hormone-Binding Globulin; Sex Steroid-Binding Protein;
Function
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Cellular Location
Secreted
In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
PTM
Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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