SIRPG

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Signal Regulatory Protein Gamma

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of T cell activationManual Assertion Based On ExperimentIDA:UniProtKB

Membrane

Extracellular: 29-360
Helical: 361-383
Cytoplasmic: 384-387