SOX13

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. [provided by RefSeq]

SOX13

Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192).
Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity).
Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity).
Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity).
Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity).
Promotes brown adipocyte differentiation (By similarity).
Inhibitor of WNT signaling (PubMed:20028982).

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell fate commitmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process gamma-delta T cell differentiationISS:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of brown fat cell differentiationISS:UniProtKB
Biological Process positive regulation of gamma-delta T cell differentiationIEA:Ensembl
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spinal cord oligodendrocyte cell differentiationISS:UniProtKB

Nucleus
Cytoplasm

Autoantibodies against SOX13 are present in sera from patients with type 1 diabetes.