Sign in or Register   Sign in or Register
  |  

Mouse Anti-SOX13 Recombinant Antibody (CBXS-2063) (CBMAB-S4829-CQ)

This product is a mouse antibody that recognizes SOX13. The antibody CBXS-2063 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SOX13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2063
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SOX13
Introduction
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.
Entrez Gene ID
9580
UniProt ID
Q9UN79
Alternative Names
SRY-Box 13; SRY (Sex Determining Region Y)-Box 13; Type 1 Diabetes Autoantigen ICA12; SRY-Related HMG-Box Gene 13; Islet Cell Antibody 12; Islet Cell Antigen 12;
Function
Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192).
Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity).
Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity).
Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity).
Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity).
Promotes brown adipocyte differentiation (By similarity).
Inhibitor of WNT signaling (PubMed:20028982).
Biological Process
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell fate commitmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process gamma-delta T cell differentiationISS:UniProtKB
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of brown fat cell differentiationISS:UniProtKB
Biological Process positive regulation of gamma-delta T cell differentiationIEA:Ensembl
Biological Process regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spinal cord oligodendrocyte cell differentiationISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
Autoantibodies against SOX13 are present in sera from patients with type 1 diabetes.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SOX13 Recombinant Antibody (CBXS-2063)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare