SRRM4

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs.

Serine / Arginine Repetitive Matrix 4

Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity).
Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677).
Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity).

Biological Process cell differentiationISS:UniProtKB
Biological Process mRNA processingISS:UniProtKB
Biological Process nervous system developmentISS:UniProtKB
Biological Process neuron maturationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of RNA splicingISS:UniProtKB
Biological Process RNA splicingIEA:UniProtKB-KW
Biological Process sensory perception of soundIEA:Ensembl

Nucleus

Phosphorylated.